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产品材料

P846 – LDA (Low Diffusable contrast Agent)

P846 – LDA (Low Diffusable contrast Agent)

470.00 

Category: Preclinical MRI probes

Description

Catalogue Number P846
Description Intermediate molecular weighted compound, constituted by a macrocyclic gadolinium chelate. Blood pharmacokinetic very comparable to that of Gd-DOTA or Gd-DTPA but limited extravasation within the capillary bed
Main Applications Contrast-Enhanced MR angiography, tissue perfusion, angiogenesis imaging (DCE, MRI, Ktrans analysis, blood volume imaging, permeability measurement, treatment follow-up)
Molecular characteristics

–  Gd content: one Gd atom per molecule

–  Hydrodynamic size: diameter is 2-3 nm

北京赛车pk10代理 –  Molecular weight: 3.5 kDa

–  Dose: due to high relaxivity of P846, the injected dose is lower than that of conventional contrast agent like Gd-DOTA

Recommended dose: 50 μmol/kg = 2.5 μL/g

北京赛车pk10代理 Example: for a 30g body weight mouse, injection volume is 75 μL

–  Relaxivities (s-1.mM-1, 37°C, Human Albumin Serum 4%)

Bo(T)

1.5

2.35

3.0

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7.1北京赛车pk10代理

r1北京赛车pk10代理

32北京赛车pk10代理

28

24

15

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r2

41

39

34

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29

 

–  In vitro quantification techniques: P846 is a Gd-based contrast agent. Gd can be dosed by ICP-AES or ICP-MS. Another way to quantify Gd chelates is by T1 or T2 relaxometry, with assumption of r1 or r2.

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Characteristics of the vial –  Concentration: [Gd] = 20 mmol/L

–  Volume: 450 μL (5 mice dose approx.)

–  Other animal species: please contact us

 

Storage Need to be stored at 4°C in a closed vial away from light
Notes For in vitro or animal use only
Selected publications [1] Peldschuss et al., Invest Radiol, 2008 [2] Lemasson et al., Radiology 2010 [3] Casneuf et al., Radiation Research 2011 [4] Heilmann et al., CMMI 2009 [5] Unpublished Guerbet data [6] Loveless, MRM 2011 [7] Jacquier et al, MAGMA 2008

Product Identification
Product Name P846
Molecular Weight
Specifications
Appearance
Identification
Analysis

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